ABSTRACT
PURPOSE: This study aimed to characterize the histopathological immunohistochemical features of chronic sclerosing sialadenitis, emphasizing the IgG4-related disease. METHODS: Seventeen cases of chronic sclerosing sialoadenitis were examined for histopathological aspects, (inflammation, fibrosis, glandular parenchyma, and lymphoid follicles) and immunohistochemistry (BCL2, CD3, CD20, CD34, CD163, p63, cyclin D1, mast cell, SMA, S100A4, IgG, and IgG4) which were scored. IgG4-related disease features were investigated. Demographic and clinical data were also collected. RESULTS: Males predominated (10:7), with an average lesion size of 3.9 cm. Common histopathological findings included reduced acinar parenchyma, lymphoid follicle formation, and ductular proliferation. CD3-positive T lymphocytes and CD34- and SMA-positive stromal fibroblasts were abundant. Nine cases (53%) showed sialoliths and three cases met the criteria for IgG4-related disease. CONCLUSION: CSS of the submandibular gland represents a reactive pattern rather than IgG4-RD as only 3 cases seemed to be related to IgG4-RD. The immunohistochemical profile revealed an abundant population of CD3-positive T lymphocytes, as opposed to regulatory proteins such as cyclin D1, demonstrating that populations of CD34- and SMA-positive stromal fibroblasts contribute to the fibrosis characteristic of CSS. In addition, our results provide a comprehensive insight into the study of CSS and its relationship with IgG4-RD.
Subject(s)
Immunoglobulin G4-Related Disease , Sialadenitis , Humans , Male , Sialadenitis/pathology , Female , Middle Aged , Adult , Immunoglobulin G4-Related Disease/pathology , Aged , Sclerosis/pathology , Chronic Disease , Submandibular Gland/pathology , ImmunohistochemistryABSTRACT
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that affects mainly children under 1 year of age. A 4-month-old boy was referred for evaluation of a lesion with 1 month of evolution. Intra-oral examination detected a firm upon palpation submucosal nodular mass, measuring 1.5 cm in diameter, affecting the anterior maxillary alveolar ridge and covered by a slightly blue mucosa with evident telangiectasia. The patient underwent an incisional biopsy and histological and immunohistochemical analyses revealed nests of AE1/AE3 positive epithelioid cells with abundant melanin pigmentation. Other cell types, resembling neuroblasts, were also present and positive for CD56, synaptophysin and enolase. The diagnosis of MNTI was established and the patient was referred for treatment. Conservative surgical resection was performed along with 3 adjacent teeth under general anesthesia. The patient is in follow-up for 1,5 year without recurrence. Conservative surgical management of MNTI may be an alternative to maxillectomy, contributing to the patient´s quality of life.
Subject(s)
Neuroectodermal Tumor, Melanotic/diagnosis , Biopsy , CD56 Antigen/metabolism , Humans , Immunohistochemistry , Infant , Male , Melanins/metabolism , Neuroectodermal Tumor, Melanotic/metabolism , Neuroectodermal Tumor, Melanotic/pathology , Neuroectodermal Tumor, Melanotic/surgeryABSTRACT
Os autores analisaram os casos de pênfigo, confirmados histopatologicamente, dos arquivos do Laboratório de Patologia Bucal da Faculdade de Odontologia de Piracicaba/UNICAMP, entre os anos de 1970 e 1998, e descreveram as características epidemiológicas da populaçäo afetada, as características clínicas da condiçäo, o curso da doença e o tratamento efetuado em 9 casos acometendo a cavidade bucal. Os resultados mostraram que a maioria das lesöes tem envolvimento mucocutâneo, curso crônico e afeta principalmente adultos do sexo feminino. O acometimento da cavidade bucal em todos os casos, a importância do diagnóstico precoce e do início do tratamento reforçam a necessidade do conhecimento dessa condiçäo pelo cirurgiäo-dentista
